Discover the Royal Messenger of Regeneration: Exosome Therapy 👑💌

Are you a STEM cell guru yet?… 👋

Well… if you’re not…

as a father, you're the king of your castle 🏰…

the ruler of your realm…

and the guardian of your family's well-being.

But even the mightiest rulers need a secret weapon to defend their health and vitality... especially as they age. 👴⚔️

Imagine if you could send tiny messengers 💌 throughout your body, carrying the blueprint for regeneration and renewal. Well, that's exactly what exosome therapy can do! 🙌 [1][2]

Exosomes are like tiny carrier pigeons 🕊️, delivering the instructions your cells need to repair, regenerate, and rejuvenate. They're the ultimate royal decree 📜 for your body to heal itself from the inside out. [3][4]

Think of exosome therapy as your secret treaty 🤝 with your own body. By harnessing the power of these microscopic messengers, you can:

1. Restore your joints and muscles to their former glory 💪👑 [5][6]
   
   

2. Revitalize your skin, hair, and nails for a regal appearance 👴➡️🤴 [7][8]
   
   

3. Boost your energy and vitality, so you can keep up with your kids and grandkids 👪👑 [9]
   
   

4. Support your body's natural defenses, like a fortified castle wall 🏰🛡️ [10]
   
   

But how do you know if your body needs an extra dose of these royal messengers? 🤔 Here are some ranges and tests to keep in mind:

RANGE: 📏
Optimal exosome concentration: 1 x 10^8 to 1 x 10^12 particles/mL [11][12]

TESTS: 🔬

1. Nanoparticle Tracking Analysis (NTA): Measures the size and concentration of exosomes [13]
   
   

2. Western Blot: Identifies specific proteins in exosomes [14]
   
   

3. Flow Cytometry: Analyzes the surface markers and purity of exosomes [15]
   
   

4. Electron Microscopy: Visualizes the structure and morphology of exosomes [16]
   
   

By embracing the royal power of exosome therapy, you can reign supreme over your health and longevity. 👑🩺 

It's like having your own personal fountain of youth, flowing with the elixir of regeneration. 🏰⛲ [17][18]

So, are you ready to claim your throne as the sovereign of your own well-being? 👑💺 

Discover the majestic potential of exosome therapy and rule your health like the king you were born to be! 🤴💪

To your royal regeneration, 🙏👑

Mens Health Secrets
–Live Past 100 🎂💯

P.S. Stay tuned for our next email, where we'll explore the cutting-edge world of gene editing and how it can help you optimize your stem cells for maximum regeneration and longevity! 🧬💪

P.P.S. Boring disclaimer: Always check with your doctor... before you start any new health protocol or treatment. This includes any recommendations from our newsletter (Mens Health Secrets). This information is for entertainment and educational purposes only... and is not a substitute for professional medical advice. Mens Health Secrets is not legally responsible for any actions you do... or not do from reading our newsletter. Sorry... had to say this legal stuff. 😴📜

P.P.P.S. >>> Go here to subscribe to our Mens Health Secrets YouTube Channel if you haven't yet…. leave a comment… and level up your Mens Health knowledge to live longer. 📺💬🧠

Medical References:

[1] Yáñez-Mó, M., Siljander, P. R. M., Andreu, Z., Bedina Zavec, A., Borràs, F. E., Buzas, E. I., ... & De Wever, O. (2015). Biological properties of extracellular vesicles and their physiological functions. Journal of Extracellular Vesicles, 4(1), 27066. https://doi.org/10.3402/jev.v4.27066

[2] Wortzel, I., Dror, S., Kenific, C. M., & Lyden, D. (2019). Exosome-mediated metastasis: communication from a distance. Developmental Cell, 49(3), 347-360. https://doi.org/10.1016/j.devcel.2019.04.011

[3] Pegtel, D. M., & Gould, S. J. (2019). Exosomes. Annual Review of Biochemistry, 88, 487-514. https://doi.org/10.1146/annurev-biochem-013118-111902

[4] Kalluri, R., & LeBleu, V. S. (2020). The biology, function, and biomedical applications of exosomes. Science, 367(6478), eaau6977. https://doi.org/10.1126/science.aau6977

[5] Wang, Y., Yu, D., Liu, Z., Zhou, F., Dai, J., Wu, B., ... & Zhang, H. (2017). Exosomes from embryonic mesenchymal stem cells alleviate osteoarthritis through balancing synthesis and degradation of cartilage extracellular matrix. Stem Cell Research & Therapy, 8(1), 1-13. https://doi.org/10.1186/s13287-017-0632-0

[6] Mao, G., Zhang, Z., Hu, S., Zhang, Z., Chang, Z., Huang, Z., ... & Wu, J. (2018). Exosomes derived from miR-92a-3p-overexpressing human mesenchymal stem cells enhance chondrogenesis and suppress cartilage degradation via targeting WNT5A. Stem Cell Research & Therapy, 9(1), 1-13. https://doi.org/10.1186/s13287-018-1004-0

[7] Kim, Y. J., Yoo, S. M., Park, H. H., Lim, H. J., Kim, Y. L., Lee, S., ... & Seo, K. W. (2017). Exosomes derived from human umbilical cord blood mesenchymal stem cells stimulates rejuvenation of human skin. Biochemical and Biophysical Research Communications, 493(2), 1102-1108. https://doi.org/10.1016/j.bbrc.2017.09.056

(MUST READ…) 

[8] Hu, L., Wang, J., Zhou, X., Xiong, Z., Zhao, J., Yu, R., ... & Chen, L. (2016). Exosomes derived from human adipose mensenchymal stem cells accelerates cutaneous wound healing via optimizing the characteristics of fibroblasts. Scientific Reports, 6(1), 1-11. https://doi.org/10.1038/srep32993

[9] Phinney, D. G., & Pittenger, M. F. (2017). Concise review: MSC-derived exosomes for cell-free therapy. Stem Cells, 35(4), 851-858. https://doi.org/10.1002/stem.2575

[10] Zhang, B., Yeo, R. W., Tan, K. H., & Lim, S. K. (2016). Focus on extracellular vesicles: therapeutic potential of stem cell-derived extracellular vesicles. International Journal of Molecular Sciences, 17(2), 174. https://doi.org/10.3390/ijms17020174

[11] Gardiner, C., Di Vizio, D., Sahoo, S., Théry, C., Witwer, K. W., Wauben, M., & Hill, A. F. (2016). Techniques used for the isolation and characterization of extracellular vesicles: results of a worldwide survey. Journal of Extracellular Vesicles, 5(1), 32945. https://doi.org/10.3402/jev.v5.32945

[12] Vogel, R., Coumans, F. A., Maltesen, R. G., Böing, A. N., Bonnington, K. E., Broekman, M. L., ... & Nieuwland, R. (2016). A standardized method to determine the concentration of extracellular vesicles using tunable resistive pulse sensing. Journal of Extracellular Vesicles, 5(1), 31242. https://doi.org/10.3402/jev.v5.31242

[13] Erdbrügger, U., & Lannigan, J. (2016). Analytical challenges of extracellular vesicle detection: A comparison of different techniques. Cytometry Part A, 89(2), 123-134. https://doi.org/10.1002/cyto.a.22795

[14] Lötvall, J., Hill, A. F., Hochberg, F., Buzás, E. I., Di Vizio, D., Gardiner, C., ... & Thery, C. (2014). Minimal experimental requirements for definition of extracellular vesicles and their functions: a position statement from the International Society for Extracellular Vesicles. Journal of Extracellular Vesicles, 3(1), 26913. https://doi.org/10.3402/jev.v3.26913

[15] Théry, C., Witwer, K. W., Aikawa, E., Alcaraz, M. J., Anderson, J. D., Andriantsitohaina, R., ... & Zuba-Surma, E. K. (2018). Minimal information for studies of extracellular vesicles 2018 (MISEV2018): a position statement of the International Society for Extracellular Vesicles and update of the MISEV2014 guidelines. Journal of Extracellular Vesicles, 7(1), 1535750. https://doi.org/10.1080/20013078.2018.1535750

[16] Yuana, Y., Koning, R. I., Kuil, M. E., Rensen, P. C., Koster, A. J., Bertina, R. M., & Osanto, S. (2013). Cryo-electron microscopy of extracellular vesicles in fresh plasma. Journal of Extracellular Vesicles, 2(1), 21494. https://doi.org/10.3402/jev.v2i0.21494

[17] Zhang, Y., Bi, J., Huang, J., Tang, Y., Du, S., & Li, P. (2020). Exosome: A review of its classification, isolation techniques, storage, diagnostic and targeted therapy applications. International Journal of Nanomedicine, 15, 6917-6934. https://doi.org/10.2147/ijn.s264498

[18] Barile, L., & Vassalli, G. (2017). Exosomes: Therapy delivery tools and biomarkers of diseases. Pharmacology & Therapeutics, 174, 63-78. https://doi.org/10.1016/j.pharmthera.2017.02.020