Stem Cells: The Exodus from Arthritis to Joint Freedom 🦿🌌

Hey there, 🙋‍♂️

Just as Moses led the Israelites out of bondage and into the Promised Land, you too can break free from the shackles of arthritis pain and embark on a journey to joint freedom. 🌿🕊️ [1]

Imagine your joints as a vast galaxy 🌌, with billions of stars ⭐ (cells) working together in perfect harmony to keep you moving smoothly. But over time, the supermassive black hole of inflammation can disrupt this delicate balance, causing pain, stiffness, and swelling. 😞🕳️ [2]

That's where stem cells come in – they're like cosmic explorers 🚀 that can navigate through the debris of damaged tissue, regenerate cartilage, and restore your joints to their former glory. 💫🦿 [3]

By harnessing the transformative power of stem cells, you can:

1. Reduce inflammation and pain, like quenching the fires of a dying star 🔥💧 [4][5]
   
   

2. Regenerate cartilage and slow down joint deterioration, like rebuilding a galaxy from stardust 🌌🔨 [6][7]
   
   

3. Improve joint flexibility and range of motion, like a supernova explosion propelling you to new heights 💥🚀 [8][9]
   
   

4. Enhance your overall quality of life, like discovering a new planet full of possibilities 🪐🌈 [10]

But how do you know if your joints are in need of a celestial intervention? 🤔 Here are some ranges and tests to keep in mind:

RANGE: 📏
Optimal synovial fluid viscosity: 10-15 Pa·s at low shear rates (0.1 s⁻¹) [11]. 📊

In simple terms, when you're at rest or moving slowly, your synovial fluid becomes thick and cushiony, like a shock-absorbing gel protecting your joints! 🛡️💧

As you move faster, your synovial fluid magically adapts, becoming thinner for effortless motion. 🎩🐇

Healthy knee cartilage thickness: 1.65-2.65 mm [12]

Studies consistently show that the thickness of healthy knee cartilage typically falls within the range of 1.5 mm to 2.7 mm…

…with some variation depending on factors such as the specific location within the joint… your age… and the measuring technique used.

TESTS: 🔬

1. MRI: Visualizes soft tissues like cartilage and ligaments [13]
   
   

2. X-ray: Detects changes in bone structure and joint space [14]
   
   

3. Arthroscopy: Allows direct visualization of joint surfaces [15]
   
   

4. Synovial fluid analysis: Evaluates inflammation and cartilage breakdown [16]

Just as King Solomon sought wisdom to govern his people, you too can make wise choices to reign over your joint health. 👑🦿 By embracing the celestial power of stem cells, you can rise above arthritis pain and restore the cosmic order to your joints. 🌠🙌

In the words of Jesus, "Ask and it will be given to you; seek and you will find; knock and the door will be opened to you." 🚪✨ [Matthew 7:7] Your journey to joint redemption awaits – are you ready to take that leap of faith? 🛸🙏

To your interstellar joint health, 🪐🚀

Mens Health Secrets
–Live Past 100 🎂💯

P.S. This may be the end of our stem cell series, but a new frontier awaits – the universe of hydrogen therapy! 🌊💦 In our next transmission, we'll explore how drinking hydrogenated water can skyrocket your health to new dimensions. Want to dive deeper? Explore the treasure trove of studies at https://hydrogenstudies.com/topics/ – your gateway to the cutting-edge cosmos of hydrogen medicine! 🚀🧬

P.P.S. Boring disclaimer: Always check with your doctor... before you start any new health protocol or treatment. This includes any recommendations from our newsletter (Mens Health Secrets). This information is for entertainment and educational purposes only... and is not a substitute for professional medical advice. Mens Health Secrets is not legally responsible for any actions you do... or not do from reading our newsletter. Sorry... had to say this legal stuff. 😴📜

P.P.P.S. >>> Go here to subscribe to our Mens Health Secrets YouTube Channel if you haven't yet…. leave a comment… and level up your Mens Health knowledge to live longer. 📺💬🧠

Medical References:

[1] Uth K, Trifonov D. Stem cell application for osteoarthritis in the knee joint: A minireview. World J Stem Cells. 2014 Nov 26;6(5):629-36. https://doi.org/10.4252/wjsc.v6.i5.629. PMID: 25426260; PMCID: PMC4178263.

[2] Freitag J, Bates D, Boyd R, Shah K, Barnard A, Huguenin L, Tenen A. Mesenchymal stem cell therapy in the treatment of osteoarthritis: reparative pathways, safety and efficacy - a review. BMC Musculoskelet Disord. 2016 May 26;17:230. https://doi.org/10.1186/s12891-016-1085-9. PMID: 27229856; PMCID: PMC4880954.

[3] Burke J, Hunter M, Kolhe R, Isales C, Hamrick M, Fulzele S. Therapeutic potential of mesenchymal stem cell based therapy for osteoarthritis. Clin Transl Med. 2016 Dec;5(1):27. https://doi.org/10.1186/s40169-016-0112-7. Epub 2016 Aug 10. PMID: 27510262; PMCID: PMC4980326.

[4] Chahla J, Piuzzi NS, Mitchell JJ, Dean CS, Pascual-Garrido C, LaPrade RF, Muschler GF. Intra-Articular Cellular Therapy for Osteoarthritis and Focal Cartilage Defects of the Knee: A Systematic Review of the Literature and Study Quality Analysis. J Bone Joint Surg Am. 2016 Sep 21;98(18):1511-21. https://doi.org/10.2106/JBJS.15.01495. PMID: 27655978.



[5] Yubo M, Yanyan L, Li L, Tao S, Bo L, Lin C. Clinical efficacy and safety of mesenchymal stem cell transplantation for osteoarthritis treatment: A meta-analysis. PLoS One. 2017 Apr 27;12(4):e0175449. https://doi.org/10.1371/journal.pone.0175449. PMID: 28448518; PMCID: PMC5407776.


[6] Cui, G.H., Wang, Y.Y., Li, C.J. et al. Efficacy of mesenchymal stem cells in treating patients with osteoarthritis of the knee: A meta-analysis. Exp Ther Med. 2016;12(5):3390-3400. https://doi.org/10.3892/etm.2016.3791

[7] Pas HI, Winters M, Haisma HJ, Koenis MJ, Tol JL, Moen MH. Stem cell injections in knee osteoarthritis: a systematic review of the literature. Br J Sports Med. 2017 Aug;51(15):1125-1133. https://doi.org/10.1136/bjsports-2016-096793. Epub 2017 Mar 3. PMID: 28258177.

[8] Lamo-Espinosa JM, Mora G, Blanco JF, Granero-Moltó F, Núñez-Córdoba JM, López-Elío S, Andreu E, Sánchez-Guijo F, Aquerreta JD, Bondía JM, Valentí-Azcárate A, Del Consuelo Del Cañizo M, Villarón EM, Valentí-Nin JR, Prósper F. Intra-articular injection of two different doses of autologous bone marrow mesenchymal stem cells versus hyaluronic acid in the treatment of knee osteoarthritis: long-term follow up of a multicenter randomized controlled clinical trial (phase I/II). J Transl Med. 2018 Jul 31;16(1):213. https://doi.org/10.1186/s12967-018-1591-7. PMID: 30064455; PMCID: PMC6069715.

[9] Song, Y., Du, H., Dai, C., Zhang, L., Li, S., Hunter, D. J., … Bao, C. (2018). Human Adipose-Derived Mesenchymal Stem Cells for Osteoarthritis: A Pilot Study with Long-Term Follow-Up and Repeated Injections. Regenerative Medicine, 13(3), 295–307. https://doi.org/10.2217/rme-2017-0152

[10] Khalifeh Soltani S, Forogh B, Ahmadbeigi N, Hadizadeh Kharazi H, Fallahzadeh K, Kashani L, Karami M, Kheyrollah Y, Vasei M. Safety and efficacy of allogenic placental mesenchymal stem cells for treating knee osteoarthritis: a pilot study. Cytotherapy. 2019 Jan;21(1):54-63. https://doi.org/10.1016/j.jcyt.2018.11.003. Epub 2018 Dec 3. PMID: 30522806.

[11] Bhuanantanondh, P., Grecov, D., & Kwok, E. (2010). Rheology of synovial fluid from patients with osteoarthritis and the effects of viscosupplements on the rheology of synovial fluid. In ASME 2010 Summer Bioengineering Conference, SBC 2010 (PARTS A AND B ed., pp. 237-238). (ASME 2010 Summer Bioengineering Conference, SBC 2010; No. PARTS A AND B). https://doi.org/10.1115/SBC2010-19543

[12] Shah RF, Martinez AM, Pedoia V, Majumdar S, Vail TP, Bini SA. Variation in the Thickness of Knee Cartilage. The Use of a Novel Machine Learning Algorithm for Cartilage Segmentation of Magnetic Resonance Images. J Arthroplasty. 2019 Oct;34(10):2210-2215. https://pmc.ncbi.nlm.nih.gov/articles/PMC7251923/. Epub 2019 Jul 24. PMID: 31445869; PMCID: PMC7251923.

[13] Florkow MC, Willemsen K, Mascarenhas VV, Oei EHG, van Stralen M, Seevinck PR. Magnetic Resonance Imaging Versus Computed Tomography for Three-Dimensional Bone Imaging of Musculoskeletal Pathologies: A Review. J Magn Reson Imaging. 2022 Jul;56(1):11-34. https://doi.org/10.1002/jmri.28067. Epub 2022 Jan 19. PMID: 35044717; PMCID: PMC9305220.

[14] Braun HJ, Gold GE. Diagnosis of osteoarthritis: imaging. Bone. 2012 Aug;51(2):278-88. https://doi.org/10.1016/j.bone.2011.11.019. Epub 2011 Dec 3. PMID: 22155587; PMCID: PMC3306456.

[15] Piuzzi NS, Slullitel PA, Bertona A, Oñativia JI, Albergo I, Zanotti G, Buttaro MA, Piccaluga F, Comba FM. Hip arthroscopy in osteoarthritis: a systematic review of the literature. Hip Int. 2016 Jan-Feb;26(1):8-14. https://doi.org/10.5301/hipint.5000299. Epub 2015 Sep 14. PMID: 26391259.

[16] Nguyen, C., Lefèvre-Colau, M.M., Poiraudeau, S., Rannou, F. Evidence and recommendations for use of intra-articular injections for knee osteoarthritis. Ann Phys Rehabil Med. 2016;59(3):184-9. https://doi.org/10.1016/j.rehab.2016.02.008